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  1. Targeting diabetic kidney disease

    ... proliferation, maturation and cell death. Now in a study published in the journal  Diabetes , Harris, Ming-Zhi Zhang, MD, ... also improved weight gain and reduced insulin resistance in mice. Their work suggests that pathways activated by EGFR may be attractive ...

    sommers - 02/21/2019 - 9:51am

  2. Heterologous Expression System for Studying Recombinant Human Brain Voltage-Gated Sodium Channel, SCN1A

    ... for Heterologous Expression System for Studying Recombinant Human Brain Voltage-Gated Sodium Channel, SCN1A Summary Isolated nucleic acids ...

    cttc_admin - 09/22/2015 - 3:47pm

  3. Researchers developing potential Coronavirus antibody therapies

    ... in humans. “Our goal is to prepare antibodies for human clinical trials by this summer,” said  James Crowe , MD, director of ... (VANTAGE). Using these techniques, they have generated human monoclonal antibodies against a wide range of pathogenic viruses ...

    sommers - 03/26/2020 - 1:36pm

  4. CTTC commercialized 25 COVID-19-related discoveries, facilitated nine startups during record-setting year

    ... rehabilitation. IDBiologics  discovers and develops human monoclonal antibodies for the prevention, treatment and cure of infectious diseases. The startup’s proprietary fully human monoclonal antibody platform enables rapid discovery and optimization of ...

    sommers - 05/26/2021 - 10:39am

  5. Antibodies discovered at Vanderbilt for prevention of COVID-19 granted FDA emergency use authorization

    ... to the global biopharmaceutical company AstraZeneca for a long-acting antibody combination that protects against COVID-19, discovered ... ultra-fast methods  to discover highly potent antiviral human monoclonal antibodies and validate their effectiveness. In June 2020, ...

    sommers - 12/10/2021 - 1:42pm

  6. Team’s findings show glutamine metabolism affects T cell signaling

    ... as a treatment for inflammatory and autoimmune diseases. The study, published online this week in the journal  Cell , also suggests ... metabolism, an enzyme called glutaminase. They also studied mice with targeted genetic deletion of the glutaminase gene. The ...

    sommers - 02/21/2019 - 9:51am

  7. “Ultra-potent” antibody against COVID-19 variants isolated at VUMC

    ... antibodies against other viruses that have not yet caused human disease but which have a high potential of doing so. “This is one ...

    sommers - 09/28/2021 - 9:45am

  8. Lickometer: Instrument for measuring rodent drinking behavior

    ... is used to measure drinking behavior in the home cage of mice.  This contact-lickometer system replaces the need for investigators ... allowing for high-throughput experimentation involving the study of rodent drinking behavior. Novelty The novelty of ...

    cttc_admin - 01/23/2024 - 2:24pm

  9. Study’s findings may help eventually close the door on COVID-19

    ... experimental viruses, such as coronaviruses that infect mice. Once the pandemic hit, Routh, Gribble and their colleagues were ... of creativity, determination — and money. Funding for this study was provided by National Institutes of Health grants AI108197, GM065086 ...

    sommers - 01/29/2021 - 12:31pm

  10. Chikungunya antibody identified at VUMC moves forward

    ... Moderna Inc. announced positive results from a phase 1 study in healthy adults of another chikungunya antibody isolated at VUMC. ... basic science discoveries into medicines that can improve human health.” During the past 25 years, Crowe and his colleagues have ...

    sommers - 03/08/2021 - 8:29am