Browse Technologies

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'Coffee Ring' Diagnostic for Point-of-Care Biomarker Detection

Bright minds at Vanderbilt University have unveiled a breakthrough technology that could bring sophisticated biomarker diagnostics to the developing world. The point-of-care diagnostic is designed to be used in the field; no specialized equipment, expertise, or white lab coats are required. The diagnostic is based upon the ingenous observation that evaporating liquid droplets leave behind a characteristic ring pattern, which may be familiar to our readers in the form of a coffee-ring stain.


A Method for Genetically Engineering Proteins with Cell Membrane Translocating Activity

The invention describes a membrane-translocating peptide sequence (MTS) which facilitates entry of polypeptides and proteins into cells. Also described is an isolated nucleotide sequence encoding the membrane-translocating peptide and a method of using this sequence to genetically engineer proteins with cell membrane permeability. The MTS, and the method of genetically engineering proteins with cell membrane permeability, are useful for polypeptide and protein delivery for human and veterinary applications such as vaccine delivery and cancer therapy.


A Robotic System for Real-time Tumor Manipulation During Image Guided Breast Biopsy

Three types of technologies have been developed for assisting during breast biopsy procedures.

1) Many robotic systems have been developed to improve accuracy of needle insertions. Butthese systems do not compensate for tumor movement during the insertion. Hence multipleinsertions are typically required to successfully sample the tumor.
2) Steerable needle devices have been developed to guide the needle tip towards the tumor.Even though these systems may not require multiple insertions, they cause tissue damageinside the breast during steering of the needle.
3) Finite element methods have been developed to predict and compensate for tumormovement. The disadvantage with this technology is that geometric and mechanicalproperties of the breast are required for finite element analysis. The average computationaltime is approximately half an hour.

We developed a novel technology for guiding clinical breast biopsy. This system positions a tumor inline with the needle during real-time needle insertion procedures. This technology solves the following problems:

- Breast biopsies can be performed without multiple needle insertions
- Expedites breast biopsy procedures
- Does not need geometric or mechanical properties of the breast
- Tissue damage inside the breast is minimized


A Sensor-Based Online Diagnostic Approach for Physical Systems

This technology addresses the problem of designing and implementing online monitoring and diagnosis systems for complex hybrid systems by focusing on faults that occur in plant components and contains models where faults are represented by changes in system parameters. Hybrid systems are common in the avionics, spacecraft, automotive and robotics domains where behavior is characterized by continuous plant dynamics and discrete supervisory control. These hybrid systems require a tool that analyzes and seamlessly integrates multiple system models on a discrete and continuous basis. As a result, tasks like monitoring, fault diagnosis and control require model selection and switching to be performed online as system behavior evolves.


A System for Growing Small Populations of Living Cells and Monitoring Their Physiological State

This invention combines the microfluidic and microelectronic devices and techniques required for the microminiaturization of cell culture and cell measurement systems to allow monitoring the response of populations of 1 to several hundred living cells. The instrument(s) allows for the detection of extracellular, membrane, and intracellular parameters; and the incorporation of closed-loop control techniques to continuously monitor the health of the cell and adjust the environmental and pharmacological parameters that control the cell.


A Two Stage ES Cell Differentiation Screen

Vanderbilt researchers have identified compounds that selectively differentiate stem cells into cardiomyocytes by perturbing key pathways. Medicinal chemistry is currently underway to develop lead compounds that maybe used for the treatment of damaged cardiac muscle.


Adjustable Universal Platform for Surgical Navigation, Approach, and Implantation

A surgical platform usable for performing a surgical procedure. In one embodiment, the surgical platform comprises a base portion configured to receive at least one probe; a plurality of adjustable legs configured to support the base portion, each adjustable legs having a first end portion and an opposite, second end potion defining a length therebetween; and at least one movable portion configured to adjust the length of at least one adjustable leg.


Algorithm for Age Related Macular Degeneration Prediction

Age-related Macular Degeneration (AMD) is the leading cause of blindness in elderly patients in developed countries, affecting approximately 7.5 million Americans. Recently several genetic and environmental factors have been implicated as susceptibility factors. We have developed an algorithm which can incorporate all of the risk factors a patient may have and determine a risk value for which they may be susceptible for developing AMD. Currently there is no predictive test for identifying individuals that are at risk for developing AMD rather individuals are screened after the age of 60 for the presence of the disease. This test would allow individuals who are at risk of developing AMD to be identified prior to onset of the disease so that preventative steps may be taken and delay or prevent AMD from occurring.


Algorithms for Compliant Insertion and Motion Control of Continuum Robots

This technology enables continuum robots (aka snake robots) to precisely navigate the intricate structures of deep anatomical passages during minimally invasive or natural orifice surgery. Collateral surgical damage is minimized by the force sensing capabilities of the algorithms used.