Browse Technologies

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'Coffee Ring' Diagnostic for Point-of-Care Biomarker Detection

Bright minds at Vanderbilt University have unveiled a breakthrough technology that could bring sophisticated biomarker diagnostics to the developing world. The point-of-care diagnostic is designed to be used in the field; no specialized equipment, expertise, or white lab coats are required. The diagnostic is based upon the ingenous observation that evaporating liquid droplets leave behind a characteristic ring pattern, which may be familiar to our readers in the form of a coffee-ring stain.


A Conditionally Lethal Helicobacter Pylori Strain

Vanderbilt University researchers have characterized an H. pylori specific gene, dapE, which can be used to generate novel, targeted therapeutics for H. pylori-induced infections in the stomach. The gene encodes an enzyme responsible for the synthesis of the amino acid lysine. Most bacterial species have redundant pathways for amino acid synthesis because they are essential for life, however H. pylori is unique in that it has only one pathway for lysine biosynthesis. In an era when antibiotic resistance has become a significant hurdle in combating bacterial infections, this gene target provides a new, antibiotic independent, modality to combat H. pylori infection. Conditionally-mutant DapE H. pylori strains can be licensed directly for use as a research tool.


A Method for Genetically Engineering Proteins with Cell Membrane Translocating Activity

The invention describes a membrane-translocating peptide sequence (MTS) which facilitates entry of polypeptides and proteins into cells. Also described is an isolated nucleotide sequence encoding the membrane-translocating peptide and a method of using this sequence to genetically engineer proteins with cell membrane permeability. The MTS, and the method of genetically engineering proteins with cell membrane permeability, are useful for polypeptide and protein delivery for human and veterinary applications such as vaccine delivery and cancer therapy.


A Method for Regulating Glucokinase by Reaction With Nitric Oxide

Vanderbilt researchers have discovered a novel mechanism through which the insulin regulating enzyme glucokinase is regulated. This discovery provides a powerful way to screen for activators of glucokinase, which may lead to therapies for diabetes.


A Novel Method for Importing Peptides with Functional Cargo Into the Cells

This technology enables the delivery of biological molecules into the interior of a cell. Such a delivery mechanism could be utilized in a variety of therapies including peptide, gene transfer and/or antisense therapy.


A peptide therapeutic for atherosclerosis that restores lipid and cholesterol homeostasis

Atherosclerosis is a serious health concern; leading to 1.5 million heart attacks in the US each year and 795,000 strokes. Vanderbilt researchers have developed a peptide therapeutic that reduces development of atherosclerosis by 63% in mice fed a Western diet. This peptide's unique mechanism attacks the problem at the level of gene expression, returning lipid synthesis to homeostatic control, while also reducing cholesterol and triglyceride levels and improving liver function.


A Robotic System for Real-time Tumor Manipulation During Image Guided Breast Biopsy

Three types of technologies have been developed for assisting during breast biopsy procedures.

1) Many robotic systems have been developed to improve accuracy of needle insertions. Butthese systems do not compensate for tumor movement during the insertion. Hence multipleinsertions are typically required to successfully sample the tumor.
2) Steerable needle devices have been developed to guide the needle tip towards the tumor.Even though these systems may not require multiple insertions, they cause tissue damageinside the breast during steering of the needle.
3) Finite element methods have been developed to predict and compensate for tumormovement. The disadvantage with this technology is that geometric and mechanicalproperties of the breast are required for finite element analysis. The average computationaltime is approximately half an hour.

We developed a novel technology for guiding clinical breast biopsy. This system positions a tumor inline with the needle during real-time needle insertion procedures. This technology solves the following problems:

- Breast biopsies can be performed without multiple needle insertions
- Expedites breast biopsy procedures
- Does not need geometric or mechanical properties of the breast
- Tissue damage inside the breast is minimized


A Sensor-Based Online Diagnostic Approach for Physical Systems

This technology addresses the problem of designing and implementing online monitoring and diagnosis systems for complex hybrid systems by focusing on faults that occur in plant components and contains models where faults are represented by changes in system parameters. Hybrid systems are common in the avionics, spacecraft, automotive and robotics domains where behavior is characterized by continuous plant dynamics and discrete supervisory control. These hybrid systems require a tool that analyzes and seamlessly integrates multiple system models on a discrete and continuous basis. As a result, tasks like monitoring, fault diagnosis and control require model selection and switching to be performed online as system behavior evolves.


A System for Growing Small Populations of Living Cells and Monitoring Their Physiological State

This invention combines the microfluidic and microelectronic devices and techniques required for the microminiaturization of cell culture and cell measurement systems to allow monitoring the response of populations of 1 to several hundred living cells. The instrument(s) allows for the detection of extracellular, membrane, and intracellular parameters; and the incorporation of closed-loop control techniques to continuously monitor the health of the cell and adjust the environmental and pharmacological parameters that control the cell.