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A Conditionally Lethal Helicobacter Pylori Strain

The invention provides the dapE gene of Helicobacter pylori and H. pylori dapE.sup.- mutants and to methods of using the mutants to express foreign genes and immunize against foreign agents. The dapE gene can consist of the nucleotide sequence defined in SEQ ID NO:3. Nucleic acids of the gidA gene and ORF 2 of H. pylori are provided. Examples of these nucleic acids can be found in SEQ ID NO:1 and SEQ ID NO:5, respectively. Having provided these nucleic acids, hybridizing nucleic acids in accord with the description of hybridizing nucleic acids of dapE are also provided.


Method to Detect PDE Inhibitor Binding

Phosphodiesterase-5 (PDE5) is an enzyme which degrades cyclic guanosine monophosphate (cGMP) in smooth muscle cells. The common known drug Viagra is similar in molecular structure to cGMP and acts as a competitive binding agent of PDE5. Thus in the presence of Viagra unbound cGMP levels increase which results in smooth muscle relaxation or vasodilation leading to an increased inflow of blood. Vanderbilt researchers have developed a method for assaying compounds which bind PDEs. Not only will this method be useful in identify other PDE inhibitors but due to the high affinity of this system this method could be used to identify and isolate PDEs from various crude tissue fractions.


Amphiphilic Polyamine Compounds

In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.


Novel PLD Inhibitors

Vanderbilt researchers have created the first isoform-selective phospholipase D (PLD) inhibitors. These highly potent inhibitors can significantly reduce PLD activity, creating a new class of anti-metastatic agents.


Microcatheter with Hemodynamic Guide Structure

A catheter device for therapeutic and diagnostic use within a human vascular system in difficult to access locations such as bifurcating cerebral arteries. The distal end of the catheter body comprises a flexible material so that the catheter tip can deflect laterally towards the vessel wall in response to the hemodynamic lift. An intermediate section of the catheter body between the hub and the tip provides a semi-rigid control connection whereby pushing, pulling, and rotation of the hub produces a corresponding movement of the catheter tip.


Novel Antimicrobial Peptide Isolated From Hydrothermal Vent-Dwelling Archaea

A new broad-spectrum antimicrobial enzyme for industrial and biopharmaceutical applications is undergoing characterization by Dr. Seth Bordenstein's laboratory at Vanderbilt University. It is expected to have unique therapeutic properties such as thermostability and tolerance of acidic environments.


Mice Expressing Homozygous Human SCN5A (the Canonical Cardiac Sodium Channel) for the Study of Long QT Syndrome

Transgenic mice homozygous for the human cardiac sodium channel SCN5A gene (human-SCN5A H/H mice), on a C57 and 129sv background. These mice can be used to study function of the post-depolarization sodium current and gender-dependent long QT-related arrhythmias.


Inventors

Dan Roden , Mark Magnuson
Research Tools
Animal Model
Cardiovascular