Scn1a Knockout Mouse Genetic Model of Epilepsy

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This is a unique genetically modified strain of mice that models Dravet syndrome, a severe infant-onset epileptic encephalopathy. They are maintained on a

pure 129S6/SvEvTac genetic background to facilitate genetic studies.

References:

Miller AR, Hawkins NA, McCollom CE, Kearney JA (2014) Mapping genetic modifiers of survival in a mouse model

of Dravet syndrome. Genes Brain Behav. 13(2):163-72.

Mistry AM, Thompson CH, Miller AR, Vanoye CG, George AL Jr, Kearney JA (2014) Strain- and age-dependent

hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice.

Neurobiol Dis. 65:1-11.