Browse Technologies

Displaying 31 - 40 of 51

Dual Interlocked Logic (DIL) Circuit

Vanderbilt researchers have developed a novel combinatorial logic circuit that prevents the propagation of signal glitches such as those caused by radiation-induced transients. The interlocked-feedback circuit accomplishes this without the loss of any speed. The circuit is designed for robustness in both combinatorial and sequential logic applications.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Jeff Maharrey, Jeffrey Kauppila, Dennis (Scooter) Ball, W.Timothy Holman, Lloyd Massengill
Category:
Computer Science & Communications General Engineering

Hyper-SHIELDED - Preserving Parahydrogen Spin Order by Efficient Transfer of Nuclear Singlet

Hyperpolarization of nuclear spin ensembles has increased NMR sensitivity to a level that is now enabling detection of metabolism in biological tissue on a time-scale of seconds. The present invention is a pulse sequence that efficiently transforms parahydrogen spin order into heteronuclear magnetization. This was achieved via a single streamlined sequence without recursive application, by finding sequential analytic solutions to the density matrix evolution for each of four independent intervals that collectively flank two proton inversions and one heteronuclear excitation. The name hyper-SHIELDED (Singlet to Heteronuclei by Interative Evolution Locks Dramatic Enhancement for Delivery) reflects the sequence's protective effect on PHIP hyperpolarization.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Kevin Waddell, Chong Cai
Category:
Medical Imaging

Latent Image-Derived Features for Prognostic Modeling

Researchers at Vanderbilt have developed a system to estimate prognostic metrics such as the length of a hospital stay, recovery status at discharge, and overall health at discharge, using only baseline imaging and clinical information gathered early in the hospital admission process. This system can assist with medical group operations and planning, it can help to educate families and patients regarding prognosis, and can be used to automatically stage patients for clinical trials.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Bennett Landman, Miya Smith, Andrew Plassard, Mayur Patel, Richard Abramson, Zhoubing Xu, Benjamin Poulose, Andrew Asman, Rebeccah Baucom, Patrick Kelly
Category:
Medical Imaging

Non-Invasive Bacterial Identification for Acute Otitis Media using Raman Spectroscopy

Vanderbilt researchers have developed an optical-based method for real-time characterization of middle ear fluid in order to diagnose acute otitis media, also knows as a middle ear infection. The present technique allows for quick detection and identification of bacteria and can also be applied to other biological fluids in vivo.

Licensing Contact

Ashok Choudhury

615.322.2503

Inventors

Anita Mahadevan-Jansen, Oscar Ayala, Eric Skaar, Catherine Wakeman, Jay Werkhaven
Category:
Diagnostics Medical Devices Medical Imaging

Non-Invasive Cell Size Detection

Vanderbilt researchers have developed a new method for using contrast enhanced MRI to non-invasively map and quantify cell size on a voxel-by-voxel basis. Using this approach, it is possible to monitor and detect diseases or treatments that alter the distribution of cell sizes such as cancer, muscular dystrophy, hepatocellular hypertrophy, and hypertrophic cardiomyopathy.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Christopher Quarles, John Gore, Natenael Semmineh
Category:
Medical Imaging

Parahydrogen-Induced Polarizer (PHIP)

The present invention provides a PANACEA (Pneumatics Allow Nonmagnetic Actuation for Creation of Enhanced Alignment) polarizer system. This is an integrated assembly of pneumatically actuated, nonmagnetic hydraulic circuits that enable PASADENA chemicals to be efficiently stored, mixed, and reacted in close proximity or within NMR magnetic fields.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Kevin Waddell
Category:
Medical Imaging

Real-time Detection of Position and Orientation of Wireless Endoscopy Capsule using Magnetic coupling

Vanderbilt researchers have developed a new system to detect the position, orientation, and pressure exerted on surrounding tissues of a wireless capsule endoscopy device.  Magnetic coupling is one of the few physical phenomena capable of transmitting actuation forces across a physical barrier.  Magnetic manipulation has the potential to make surgery less invasive, by allowing untethered miniature devices to enter the body through natural orifices or tiny incisions, and then maneuver with minimal disruption to healthy tissue.  In order to accomplish this goal, the pose (position and orientation) of the medical device must be available in real time.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Pietro Valdastri, Marco Beccani, Christian Di Natali, Keith Obstein
Category:
Medical Devices Medical Imaging

Selective Size Imaging using Filters via Diffusion Times (SSIFT)

Vanderbilt researchers have developed a novel MRI-based method for fast, robust, and accurate imaging of biological tissue by selecting a specific cell size range (such as tumors) without the need for a contrast agent. One exciting application of this method is imaging brain metastases (BM) that are difficult to differentiate from other brain abnormalities such as radionecrosis when using existing approaches.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Junzhong Xu
Category:
Medical Imaging

pECHO: Easy to Use Smartphone App for Assisting in Transesophageal Echocardiography Exam

Transesophageal echocardiography (TEE) is a test that uses high-frequency sound waves to create images of the heart. It provides more detail that a standard echocardiogram. Vanderbilt researchers have created a software that creates an easy to follow, step-by-step procedure for a transesophageal echocardiography exam.

Licensing Contact

Masood Machingal

615.343.3548

Inventors

Bantayehu Sileshi, Marc Gutierrez
Category:
Computer Science & Communications Health Care IT Medical Imaging
Field of Use:
Cardiovascular

PANORAMIC: Precession and Nutation for Observing Rotation at Multiple Intervals about the Carrier

Methods of hyperpolarization based on parahydrogen have been expanding recently from the early applications in hydrogenation chemistry to biomedical imaging where they are expected to yield similar information as the competing technology, dynamic nuclear polarization, (DNP). These hyperpolarization experiments have already enabled the measurement of metabolism in vivo at temporal resolutions of seconds. When infused into organisms harboring tumor cells, molecules such as pyruvate and lactate have been shown to be sufficiently long-lived to infiltrate cellular metabolic cycles and be converted at different rates in cancer versus normal tissue. DNP has been used most frequently in these early studies, owing to commercial availability and the flexibility to polarize small molecules such as pyruvate and lactate. Techniques based on chemical addition or exchange of parahydrogen have also shown promise for generating metabolic contrast in vivo at similar levels of signal enhancement and at lower costs.

Licensing Contact

Chris Harris

615.343.4433

Inventors

Kevin Waddell
Category:
Medical Imaging