Browse Technologies

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Use of Fluid Shear Stress Treatment to Enhance T Cell Activation

Researchers at Vanderbilt University have developed a technique to enhance immune cell activation by exposing cells to mechanical force while culturing. Proof-of-concept data indicate that activating immune cells with this method may improve therapeutic efficacy and reduce manufacturing expenses, making powerful CAR T cell therapies more accessible to patients in need.


Licensing Contact

Cameron Sargent

615.322.5907

PIQASO: A rigid phantom for comprehensive end-to-end evaluation of online adaptive radiotherapy systems

There is currently no radiotherapy phantom capable of quantitatively assessing all components of an online adaptive radiotherapy (online ART) system in a comprehensive end-to-end test.Represented here is a novel, rigid phantom that can simultaneously evaluate an online ART system's image acquisition, deformable image registration, contour propagation, plan re-optimization, dose calculation, and beam delivery in a single process that is robust, quantitative, and convenient.


Licensing Contact

Masood Machingal

615.343.3548

Improved Biomanufacturing Using Biological Clock Control for High Yield/Low Cost Bioproduct

A team of researchers at Vanderbilt University has developed a method of manipulating the circadian clock of cyanobacteria. This biological manipulation is used to increase gene expression in target genes that produce biofuel and high-value bioproducts, such as pharmaceuticals and cosmetics from precursor-expressing genes. Altering the circadian rhythm in the bacteria provides an improved approach to bioproduct development on a large scale using sunlight as a zero--cost energy solution.


Licensing Contact

Masood Machingal

615.343.3548

Inexpensive Disposable Hydro-Jet Capsule Robot for Gastric Cancer Screening in Low-Income Countries

Gastric cancer is the second leading cause of cancer death worldwide. While screening programs have had a tremendous impact on reducing mortality, the majority of cases occur in low and middle-income countries (LMIC). Typically, screening for gastric and esophageal cancer is performed using a flexible endoscope; however, endoscopy resources for these settings are traditionally limited. With the development of an inexpensive, disposable system by Vanderbilt researchers, gastroscopy and colonoscopy can be facilitated in areas hampered by a lack of access to the appropriate means.


Licensing Contact

Masood Machingal

615.343.3548

A Method to Obtain Uniform Radio Frequency Fields in the Body for High Field MRI

Researchers at Vanderbilt have created a new approach to produce uniform radio frequency (RF) fields in the body during high field magnetic resonance imaging (MRI). Existing high field MRI machines create non-uniform RF fields that lead to non-uniform sensitivity in the generated images, also referred to as "hot" and "cold" spots. These local variations interfere with the tissue contrast of the images that radiologists depend upon to make accurate diagnoses. By generating uniform RF fields in the body, this technology provides the benefits of high field MRI without the non-uniform RF fields.


Licensing Contact

Chris Harris

615.343.4433
Medical Imaging

A Novel Organs-On-Chip Platform

Vanderbilt researchers have created a new multi-organs-on-chip platform that comprises Perfusion Control systems, MicroFormulators, and MicroClinical Analyzers connected via fluidic networks. The real-time combination of multiple different solutions to create customized perfusion media and the analysis of the effluents from each well are both controlled by the intelligent use of a computer-operated system of pumps and valves. This permits, for the first time, a compact, low-cost system for creating a time-dependent drug dosage profile in a tissue system inside each well.


Licensing Contact

Ashok Choudhury

615.322.2503

Enhanced Optical Imaging for the Treatment of Retinal Disease

Vanderbilt researchers have developed a system for enhancing the imaging capabilities of optical coherence tomography (OCT), a tool commonly used to monitor and treat patients with retinal disease. The image resolution of OCT, however, is intrinsically limited. Ideally, a contrast agent could be used to highlight specific parts of the retina within the image, but dye alone is largely ineffective because of the way OCT generates the image. Photothermal heating solves this problem by creating local zones of tissue expansion which can be distinctly detected by OCT. Photothermal-OCT is safe, effective, and enhances the imaging power of a tool widely used by opticians.


Licensing Contact

Philip Swaney

615.322.1067
Medical Imaging

Systems and Methods for Non-destructive Evaluation of Optical Material Properties and Surfaces

A team of Vanderbilt researchers has developed a novel system and method for non-destructive characterization of compound lenses. The approach uses optical coherence tomography and reflectance confocal microscopy to fully characterize lens geometry and glass materials, enabling accurate modeling of compound lenses.


Licensing Contact

Philip Swaney

615.322.1067
Medical Imaging

Bioresorbable RF Coils for Post-Surgical Monitoring by MRI

Vanderbilt researchers have developed bioresorbable RF coils to improve the signal-to-noise ratio (SNR) for use in post-surgical monitoring.


Licensing Contact

Chris Harris

615.343.4433

Inventors

Mark Does, John Rogers

Innovative Mobile App that Facilitates Self-Management in Diabetes

Vanderbilt researchers have developed the MyDay mobile app (iOS/Android) designed to collect, integrate, and provide feedback on a wide range of individual data relevant for diabetes self-management which allows flexible creation of data collection content, format, and timing.


Licensing Contact

Masood Machingal

615.343.3548